Histopathology, pharmacokinetics and estimation of interleukin-6 levels of Moringa oleifera leaves extract-functionalized selenium nanoparticles against rats induced hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) is one of the most dangerous cancers in all world. This study focused on prevention and therapy hepatocellular using Moringa oleifera extract combined with vitamin C selenium a nanoplatform (MO/asc.-Se-NPs). Results Full characterization MO/asc.-Se-NPs was performed by different analytical techniques (TEM, DLS, zeta-sizer), its antioxidant capacity measured DPPH assay. Biodistribution aid radiolabeling technique technetium-99m normal albino mice. HCC induced Wister rats to evaluate efficiency treatment HCC. The biomarker analysis (ALT, AST ALB) shows improvement values treated groups MO/asc.-Se NP. levels inflammatory marker interleukin 6 (IL6 tissue homogenate) improved decreasing these two also. Histology section liver showed alleviation groups. Conclusions In conclusion, can be used as potential agent for after further preclinical studies.